Encyclopaedia Of Gene Therapy: Tools And Potential Applications

 

 

 

Encyclopaedia of Gene Therapy: Tools and Potential Applications

by Garijo Daniel

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publisher: Koros Press Limited; Combined volume edition (April 1, 2017)
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isbn: 1785693298, 978-1785693298,
weight: 1.7 pounds
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This,book,allows,people,to,come,across,using,the,opinions,of,experts,inside,the,gene,therapy,fieldIn,,,a,,,recessive,,,genetic,,,disease,,,,both,,,copies,,,of,,,a,,,given,,,gene,,,are,,,defectiveAnother,,three,,children,,were,,making,,progress.[18],,In,,2014,,a,,further,,18,,children,,with,,ADA-SCID,,were,,cured,,by,,gene,,therapy.[112],,ADA-SCID,,children,,have,,no,,functioning,,immune,,system,,and,,are,,sometimes,,known,,as,,"bubble,,children."[18]Twelve,,years,,later,,,she,,still,,demonstrates,,reasonable,,levels,,of,,ADA,,activity,,,but,,the,,gene,,therapy,,was,,not,,a,,cure,,as,,she,,must,,continue,,to,,receive,,the,,standard,,enzyme,,replacement,,therapy,,to,,maintain,,her,,health"Gene,,,Therapy,,,for,,,Human,,,Genetic,,,Disease?"

 

PMC1193620These,,,methods,,,include,,,electroporation,,,(local,,,destabilization,,,of,,,the,,,cell,,,membrane,,,using,,,an,,,electric,,,pulse),,,,sonoporation,,,(membrane,,,destabilization,,,using,,,ultrasound),,,or,,,laser,,,irradiation,,,(introduction,,,of,,,transient,,,pores,,,in,,,the,,,membrane,,,using,,,a,,,lens-focussed,,,laser,,,beam)InTech,,uses,,cookies,,to,,offer,,you,,the,,best,,online,,experienceR.;,,,Kattenhorn,,,,L(2004)One,,of,,the,,early,,successes,,of,,gene,,therapy,,was,,for,,a,,four-year-old,,girl,,with,,adenine,,deaminase,,(ADA),,deficiency6Cationic,polymers,have,been,used,to,condense,and,deliver,genetic,material,,including,poly(l-lysine),(PLL),,polyethylenimine,(PEI),,chitosan,and,polyamidoamine,(PAMAM),[7]

 

Spider,silk-based,gene,carriers,for,tumor,cell-specific,deliveryThere,,are,,many,,techniques,,of,,gene,,therapy,,,all,,of,,them,,still,,in,,experimental,,stagesThe,,,initial,,,approach,,,incorporated,,,DNA,,,into,,,an,,,engineered,,,virus,,,to,,,deliver,,,the,,,DNA,,,into,,,a,,,chromosome.[30][31],,,Naked,,,DNA,,,approaches,,,have,,,also,,,been,,,explored,,,,especially,,,in,,,the,,,context,,,of,,,vaccine,,,development.[32]Positive,,,charge,,,is,,,essential,,,to,,,ensure,,,interaction,,,of,,,the,,,nanoparticle,,,with,,,its,,,target,,,cell,,,,however,,,the,,,mononuclear,,,phagocytic,,,system,,,(MPS),,,eliminates,,,foreign,,,hydrophobic,,,particles,,,from,,,the,,,circulation,,,[7],,,by,,,opsonisationB.;,Boye,,SAdv,,Drug,,Deliv,,Rev,,2011,,Mar,,18;63(3):129-130Gene,Ther,2007,Jan;14(1):68-77

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